Photo by: Caitlin Abrams
Prof. Robert Vince featured on Mpls.StPaul Magazine
Life Saver: Robert Vince, a Minnesota superhero, creates drugs to combat diseases like AIDS and cancer.
Prof Wang Awarded NIH Grant
Congratulations to Prof. Zhengqiang Wang for being awarded a new 5 year grant by NIH
Structural studies of HIV Capsid with host factors and Capsid-targeting antivirals
Funding Agency: NIH/NIAID
Type: Multiple PI R01
PI(s): Stefan Sarafianos, PhD & Zhengqiang Wang, PhD
Research on Alzheimer's Disease by Prof Vince and Prof More Featured on C&EN News
Eye Test Might One Day Diagnose Alzheimer’s Before Symptoms Appear
Prof Swati More and Prof Robert Vince have developed a noninvasive imaging technique that tracks accumulation of the Alzheimer’s peptide, amyloid-β, in the eye. The pair have peered into the retinas of mice with their patented, microscope-based method, they hope to one day use it to identify Alzheimer’s disease in human patients years before symptoms manifest.
OakleyOriginals/CC 2.0/ flic.kr/p/5pjoeg
Prof Chen's Research on Parkinson’s Disease featured by the University
Drug Design for Parkinson’s Disease Starts Here
Recently, University of Minnesota Center for Drug Design member, organic chemist and assistant professor Prof Liqiang Chen, published a paper in the Journal of Medicinal Chemistry outlining the discovery of a potent and selective protein-inhibitor. Blocking the protein, Sirtuin 2 (SIRT2), also has the potential to block a primary contributor to Parkinson’s disease from causing harm.
Message from the Director
Robert Vince, PhD
The Center for Drug Design (CDD) was created to combine research and scholarship leading to the development of novel drugs for therapeutic applications, such as HIV, cancer, neurological diseases, dermatological agents, infectious diseases, novel processes, and medical devices. The Center for Drug Design combines the best of academic tradition along with an expectation of innovation and independence, and provides significant value for our academic and research community.
Yihong Ye, PhD
Protein Stability and Quality Control Section
Laboratory of Molecular Biology
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Title: Protein Quality Control and Cancer Therapy
To safeguard proteomic integrity, eukaryotic cells rely on the ubiquitin proteasome system to degrade aberrant polypeptides and the autophagy pathway to eliminate protein aggregates. Inhibition of these protein quality control (PQC) systems in cells leads to unbalanced protein homeostasis (proteostasis) network, which culminates in cell death. Many types of cancer cells are particularly sensitive to perturbed proteostasis network given their strong reliance on protein synthesis for growth. As a result, targeting PQC pathways has been demonstrated to be an effective therapeutics for certain types of cancer. The presentation will discuss the mechanism of endoplasmic reticulum-associated degradation (ERAD), a PQC mechanism that degrades misfolded ER proteins, and the possibility of targeting key ERAD regulators in cancer therapy. A novel PQC pathway that might be a potential anti-cancer target will also be discussed.
Date: October 21, 2015 Time: 10:30 - 11:30 AM Venue: 1-451 Moos Tower
Spotlight on Research
A faster acting and safer than existing options, an antidote for cyanide poisoning that works prophylactically to prevent or limit toxicity associated from exposure to cyanide has been developed.