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Z. Wang - Structural studies of HIV Capsid with host factors and Capsid-targeting antivirals

Z. Wang - Structural studies of HIV Capsid with host factors and Capsid-targeting antivirals


Structural studies of HIV Capsid with host factors and Capsid-targeting antivirals
Grant Number: 5R01AI120860-02
Duration: 06/15/2015—05/31/2020
Funding Agency: NIH/NIAID
Type: Multiple PI R01
Principal Investigator(s): Stefan Sarafianos, PhD (contact) and Zhengqiang Wang, PhD
Total UMN Award: $760,000

 

C. Salomon - New therapeutic strategies for combating biofilm associated pathogens

C. Salomon - New therapeutic strategies for combating biofilm associated pathogens

New therapeutic strategies for combating biofilm associated pathogens
Duration: 10/2014-10/2016
Funding Agency: Center for Drug Design, UMN
Investigator(s):  Christine Salomon, PhD (PI)

R. Geraghty - Identification of Small Molecule Inhibitors of Viral Endonucleases

R. Geraghty - Identification of Small Molecule Inhibitors of Viral Endonucleases

Identification of Small Molecule Inhibitors of Viral Endonucleases
7/1/14 – 6/30/16
Center For Drug Design
Research Development and Seed Grant
Role: PI Robert Geraghty, PhD; Co-Investigator Z. Wang

Z. Wang - Structure-Based Discovery of Tyrosyl DNA Phosphodiesterase 2 (TDP2) Inhibitors

Z. Wang - Structure-Based Discovery of Tyrosyl DNA Phosphodiesterase 2 (TDP2) Inhibitors

Structure-Based Discovery of Tyrosyl DNA Phosphodiesterase 2 (TDP2) Inhibitors
Faculty Research Development Grant, Academic Health Center, University of Minnesota  
Co-PIs: H. Aihara, PhD; Zhengqiang Wang, PhD (contact PI)
07/01/2014—06/30/2016
The goal of this grant is to discover novel hTdp2 inhibitors and obtain their co-crystal structures with hTdp2 to allow understanding on inhibitory mechanism and provide a platform for Tdp2 drug discovery efforts.

Z. Wang - Fragment Based Library Synthesis toward Small Molecule Inhibitors of Tdp2 and HBV Capsid

Z. Wang - Fragment Based Library Synthesis toward Small Molecule Inhibitors of Tdp2 and HBV Capsid

Fragment Based Library Synthesis toward Small Molecule Inhibitors of Tdp2 and HBV Capsid
Research Development and Seed Grant,
Center for Drug Design, University of Minnesota
PI: Zhengqiang Wang, PhD 
07/01/2014—06/30/2016
The goal of this grant is to curate and synthesize libraries of fragments and combined fragments for Tdp2 inhibitor discovery and extend a similar approach to identifying small molecular inhibitors of HBV capsid

C. Salomon - Harnessing microbes from the Soudan Mine: Bioremediation, Biocontrol and Bioenergy

C. Salomon - Harnessing microbes from the Soudan Mine: Bioremediation, Biocontrol and Bioenergy

Harnessing microbes from the Soudan Mine: Bioremediation, Biocontrol and Bioenergy
Duration: 07/2013 - 06/2016
Funding Agency: Legislative-Citizen Commission on Minnesota Resources (LCCMR)
Investigator(s): Christine Salomon, PhD (PI), Jeff Gralnick, PhD (Co-I); Brandy Toner, PhD (Co-I); Robert Blanchette, PhD (Co-I), Daniel Bond, PhD (Co-I)

Z. Wang - Novel Antivirals Targeting the RNase H Activity of HIV Reverse Transcriptase

Z. Wang - Novel Antivirals Targeting the RNase H Activity of HIV Reverse Transcriptase

Novel Antivirals Targeting the RNase H Activity of HIV Reverse Transcriptase
Grant Number: 1R01AI100890-01A1 
Duration: 07/01/2012—06/30/2017
Funding Agency: NIH/NIAID
Type: Multiple PI R01
Principal Investigator(s): Michael A. Parniak, PhD; Stefan Sarafianos, PhD; Zhengqiang Wang, PhD
Total UMN Award: $1,122,840

The goal of this grant is to identify and optimize selective inhibitors of HIV RNase H and study detailed biochemistry of different modes of RNase H activities as well as inhibitor binding sites, and eventually validate RNase H as an antiviral target for HIV chemotherapy. 

C. Salomon - Evaluation and development of colomitide C as a therapeutic for breast cancer

C. Salomon - Evaluation and development of colomitide C as a therapeutic for breast cancer

Evaluation and development of colomitide C as a therapeutic for breast cancer
Duration: 06/2012-06/2015
Funding Agency: Center for Drug Design, UMN
Investigator(s):  Christine Salomon, PhD (PI)

C. Salomon - Interspecies Signaling Interactions and Pathogen Suppression Among Soilborne Streptomyces

C. Salomon - Interspecies Signaling Interactions and Pathogen Suppression Among Soilborne Streptomyces

Interspecies Signaling Interactions and Pathogen Suppression Among Soilborne Streptomyces
Duration: 03/2011 - 02/2015
Funding Agency: United States Department of Agriculture (USDA)
Investigator(s): Christine Salomon, PhD (PI); Linda L. Kinkel, PhD (Co-PI)

R. Geraghty - Receptor recognition mechanisms of coronaviruses

R. Geraghty - Receptor recognition mechanisms of coronaviruses

Receptor recognition mechanisms of coronaviruses
6/1/10 – 5/31/15
R01 AI089728                NIH/NIAID
This proposal seeks to characterize the interactions between group I and group II coronavirus envelope glycoproteins and their cell surface receptors. (10% effort).
Role:  Robert Geraghty, PhD (Co-Investigator); Fang Li, PhD (Principal Investigator)