Abbas Raza, PhD

Research Assistant Professor, Center for Drug Design (CDD)

Abbas Raza

Contact Info

razax003@umn.edu

Office Phone 612-624-2146

Office Address:
Nils Hasselmo Hall, 4-270
312 Church St SE
Minneapolis, MN 55455

Mailing Address:
MMC 204
312 Church St SE
Minneapolis, MN 55455

Research Assistant Professor, Center for Drug Design (CDD)


Indian Institute of Chemical Technology (Organic Chemistry)

University of Hyderabad (Chemistry)

Summary

Research

Research Summary/Interests

Dermatology:
Design of functional cosmetic ingredients
Biomimetic DNA repair and anti-skin aging approaches
New photoprotection strategies (Solar UV)

Vitamin C:
In addition to being an antioxidant, ascorbic acid (AA) in its oxidized form, dehydroascorbic acid (DHA) has many important biological functions beyond the AA–DHA cycle. Current research include exploring the other facets of this important molecule and use the knowledge to make an effective dug like molecule.

Antiviral:
HIV-1 Protease inhibitors
HCV NS3 Protease inhibitors

Patents

  • Vince, R, Raza, A and Dreis C. Open Chained OR Fused 1, 1 '-Alkylene-Bis-Uracil Derivatives, Useful in Skin UV-Protection, US 2015 231051 A1
  • Vince, R, Raza, A and Dreis C.Sunless Tanning Compounds and Compositions, WO 2015 003095A1
  • Vince, R, Raza, A and Dreis C. Agents that Prevent or Repair Skin Damage, US 2014 350036 A1
  • Vince, R, Raza, A and Dreis C. Agents that Prevent or Repair Skin Damage, PCT Appl. No. PCT/US2013/021259, 2013

Publications

  • Topical Acyclothymidine Dinucleosides (aTds) Promote non-UV Mediated Endogenous Defense Mechanisms in Guinea Pig Skin. Nugent, S. N, Vince, R. Raza, A. J. Invest. Dermatol. 2015, 135, 1687-89.
  • A Bio-Mimetic Approach to DNA Photoprotection Raza, A.; Ericson, M. E.; Nugent, J. S.; Dreis, C. D.; Vince, R. J. Invest. Dermatol. 2014, 134, 559–562.
  • Photoprotection of DNA (in vitro) by acyclothymidine dinucleosides. Raza, A.; Dreis, C. D.; Vince, R. Bioorg Med Chem Lett. 2013, 23(3), 620-3.
  • The Butter Flavorant, Diacetyl, Forms a Covalent Adduct with 2-Deoxyguanosine, Uncoils DNA, and Leads to Cell Death. More, S. S.; Raza, A; Vince, R. J. Agric. Food Chem. 2012, 60 (12), 3311-3317.
  • Dehydroascorbic Acid Adducts of Guanosine Residues: Possible Biological Implications. Raza, A. and Vince, R. ChemBioChem 2011, 12, 1015-1017.
  • Design and synthesis of sulfoximine based inhibitors for HIV-1 protease. Raza, A.; Sham, Y. Y. and Vince, R. Bioorg. Med. Chem. Lett. 2008, 18, 5406-5410.
  • Solid-Phase Synthesis of Isoxazolines. Raza, A.; Reddy, M. V.; Yadav, J. S; Chandrasekhar, S. J. Comb. Chem. 2002, 4(6), 652-655.
  • Synthesis of unusual amino acids: N-(tert-butoxycarbonyl)-L-vinyl glycine and N-(tert-butoxycarbonyl)-L-homophenylalanine. Raza, A.; Takhi, M.; Chandrasekhar, S. Tet. Asymm. 2002, 13(4), 423-428.
  • A New Cleavage Strategy for Ester Linked Polymer Supports: Generation of a Tertiary Alcohol Library. Padmaja, M. B.; Raza, A.; Chandrasekhar, S. J. Comb. Chem. (2000), 2(3), 246-248.
  • Solid phase-solid state synthesis of N-alkyl imides from anhydrides. Padmaja, M.B.; Raza, A.; Chandrasekhar, S. Synlett, 1999, 1597.
  • Novel solid-state reduction of organic functional groups on solid support (Merrifield's resin). Raza, A.; Padmaja, M. B.; Chandrasekhar, S. Synlett 1999, (7), 1061-1062.
  • One pot synthesis of acetylated homoallyl alcohols. Mohanty, P. K.; Raza, A.; Chandrasekhar, S. Synth. Commun. 1999, 29(2), 257-262.