Daniel J. Wilson

Research Fellow, Center for Drug Design (CDD)

Daniel J. Wilson

Contact Info

wils0125@umn.edu

Office Phone 612-625-7958

Office Address:
Nils Hasselmo Hall
312 Church St SE
Minneapolis, MN 55455

Mailing Address:
MMC 204
312 Church St SE
Minneapolis, MN 55455

Biotechnology Institute, University of Minneapolis

Research

Research Summary/Interests

My current research is centered on the biochemical characterization of inhibitors and development of convenient assays for enzymes from Mycobacterium tuberculosis. I use a variety of techniques including, isothermal titration calorimetry (ITC), fluorescence polarization (FP), mass spectrometry, NMR, and radioassays.

Publications

  • Xue, Y. Q., D. Wilson, et al. (1998). "Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae." Chemistry & Biology 5(11): 661-667.
  • Xue, Y. Q., D. Wilson, et al. (2000). "Genetic architecture of the polyketide synthases for methymycin and pikromycin series macrolides." Gene 245(1): 203-211.
  • Wilson, D. J., Y. Q. Xue, et al. (2001). "Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae." Journal of Bacteriology 183(11): 3468-3475.
  • Rejman, D., M. Olesiak, et al. (2006). "Novel methylenephosphophosphonate analogues of mycophenolic adenine dinucleotide. Inhibition of inosine monophosphate dehydrogenase." Journal of Medicinal Chemistry 49(16): 5018-5022.
  • Somu, R. V., D. J. Wilson, et al. (2006). "Antitubercular nucleosides that inhibit siderophore biosynthesis: SAR of the glycosyl domain." Journal of Medicinal Chemistry 49(26): 7623-7635.
  • Vannada, J., E. M. Bennett, et al. (2006). "Design, synthesis, and biological evaluation of beta-ketosulfonamide adenylation inhibitors as potential antitubercular agents." Organic Letters 8(21): 4707-4710.
  • Chen, L. Q., G. Y. Gao, et al. (2007). "Methylenebis(sulfonamide) linked nicotinamide adenine dinucleotide analogue as an inosine monophosphate dehydrogenase inhibitor." Bioorganic & Medicinal Chemistry Letters 17(11): 3152-3155.
  • Chen, L. Q., G. Y. Gao, et al. (2007). "Probing binding requirements of type I and type II Isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues." Journal of Medicinal Chemistry 50(23): 5743-5751.
  • Chen, L. Q., D. Wilson, et al. (2007). "Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment." Journal of Medicinal Chemistry 50(26): 6685-6691.
  • Qiao, C. H., A. Gupte, et al. (2007). "5 '-O-[(N-Acyl)sulfamoyl]adenosines as antitubercular agents that inhibit MbtA: An adenylation enzyme required for siderophore biosynthesis of the mycobactins." Journal of Medicinal Chemistry 50(24): 6080-6094.
  • Qiao, C. H., D. J. Wilson, et al. (2007). "A mechanism-based aryl carrier protein/thiolation domain affinity probe." Journal of the American Chemical Society 129(20): 6350.
  • Wang, Z. Q., E. M. Bennett, et al. (2007). "Rationally designed dual inhibitors of HIV reverse transcriptase and integrase." Journal of Medicinal Chemistry 50(15): 3416-3419.
  • Chen, L. Q., R. Petrelli, et al. (2008). "Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: Inhibition of inosine monophosphate dehydrogenase." Bioorganic & Medicinal Chemistry 16(15): 7462-7469.
  • Chen, L. Q., D. J. Wilson, et al. (2008). "Mycophenolic acid analogs with a modified metabolic profile." Bioorganic & Medicinal Chemistry 16(20): 9340-9345.
  • Gupte, A., H. I. Boshoff, et al. (2008). "Inhibition of Siderophore Biosynthesis by 2-Triazole Substituted Analogues of 5'-O-[N-(Salicyl)sulfamoyl]adenosine: Antibacterial Nucleosides Effective against Mycobacterium tuberculosis." Journal of Medicinal Chemistry 51(23): 7495-7507.
  • Neres, J., N. P. Labello, et al. (2008). "Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: Structure-activity relationships of the nucleobase domain of 5 '-O-[N-(salicyl)sulfamoyl]adenosine." Journal of Medicinal Chemistry 51(17): 5349-5370.
  • Neres, J., D. J. Wilson, et al. (2008). "Aryl Acid Adenylating Enzymes Involved in Siderophore Biosynthesis: Fluorescence Polarization Assay, Ligand Specificity, and Discovery of Non-nucleoside Inhibitors via High-Throughput Screening." Biochemistry 47(45): 11735-11749.
  • Petrelli, R., Y. Y. Sham, et al. (2009). "Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues." Bioorganic & Medicinal Chemistry 17(15): 5656-5664.
  • Chen, L. Q., R. Petrelli, et al. (2010). "Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure." Bioorganic & Medicinal Chemistry 18(16): 5950-5964.
  • Chen, L. Q., D. J. Wilson, et al. (2010). "Triazole-Linked Inhibitors of Inosine Monophosphate Dehydrogenase from Human and Mycobacterium tuberculosis." Journal of Medicinal Chemistry 53(12): 4768-4778.
  • Sikora, A. L., D. J. Wilson, et al. (2010). "Kinetic and Inhibition Studies of Dihydroxybenzoate-AMP Ligase from Escherichia coli." Biochemistry 49(17): 3648-3657.
  • Vasan, M., J. Neres, et al. (2010). "Inhibitors of the Salicylate Synthase (MbtI) from Mycobacterium tuberculosis Discovered by High-Throughput Screening." Chemmedchem 5(12): 2079-2087.
  • Wilson, D. J. and C. C. Aldrich (2010). "A continuous kinetic assay for adenylation enzyme activity and inhibition." Analytical Biochemistry 404(1): 56-63.
  • Felczak, K., L. Q. Chen, et al. (2011). "Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: Targeting the pyrophosphate binding sub-domain." Bioorganic & Medicinal Chemistry 19(5): 1594-1605.
  • Park, S. W., M. Klotzsche, et al. (2011). "Evaluating the Sensitivity of Mycobacterium tuberculosis to Biotin Deprivation Using Regulated Gene Expression." Plos Pathogens 7(9).
  • Shi, C., T. W. Geders, et al. (2011). "Mechanism-based Inactivation by Aromatization of the Transaminase BioA Involved in Biotin Biosynthesis in Mycobaterium tuberculosis." Journal of the American Chemical Society 133(45): 18194-18201.
  • Wilson, D. J., C. Shi, et al. (2011). "A continuous fluorescence displacement assay for BioA: An enzyme involved in biotin biosynthesis." Analytical Biochemistry 416(1): 27-38.
  • Sundlov, J. A., C. Shi, et al. (2012). "Structural and Functional Investigation of the Intermolecular Interaction between NRPS Adenylation and Carrier Protein Domains." Chemistry & Biology 19(2): 188-198.