Jing Tang, PhD

Research Assistant Professor - Wang Group, Center for Drug Design (CDD)

Jing Tang

Contact Info

tangx252@umn.edu

Office Phone 612-626-3626

Fax 612-625-8154

Office Address:
7-228 Phillips-Wangensteen Building
516 Delaware St SE
Minneapolis, MN 55455

Mailing Address:
MMC 204
312 Church St SE
Minneapolis, MN 55455

Research Assistant Professor - Wang Group, Center for Drug Design (CDD)


PhD, Zhejiang University (Organic Chemistry)

Summary

Research

Research Summary/Interests

  • Design and synthesis of dual inhibitors of HIV reverse transcriptase and integrase
  • Design, synthesis, and SAR of novel active site directed HIV RNase H inhibitors
  • Synthesis and SAR of novel HCV NS5B inhibitors

Patents

  • Small-molecule botulinum toxin inhibitors. Pang, Y.; Millard, C.; Park, J.; Tang, J.; Schmidt, J.; U.S. Patent.
  • Wang, Z.; Geraghty, R.; Vince, R.; Tang, J.; N-Hydroxypyrimidine-2,4-diones as inhibitors of HIV and HCV.; U.S. Patent.

Publications

  • Chen, Y.-L.; Tang, J.; Kesler, M. J.; Sham, Y. Y; Vince, R.; Geraghty, R. J.; Wang, Z. " The Design, Synthesis and Biological Evaluations of C-6 or C-7 Substituted 2-Hydroxyisoquinoline-1,3-diones as Inhibitors of Hepatitis C Virus ", Bioorg. Med. Chem. 2012, 20, 467-479.
  • Tang, J.; Maddali, K.; Metifiot, M.; Sham, Y. Y; Vince, R.; Pommier, Y.; Wang, Z. "3-Hydroxypyrimidine-2,4-diones as an Inhibitor Scaffold of HIV Integrase", J. Med. Chem. 2011, 54, 2282-2292.
  • Tang, J.; Maddali, K.; Dreis, C. D.; Sham, Y. Y; Vince, R.; Pommier, Y.; Wang, Z. "6-Benzoyl-3-hydroxypyrimidine-2,4-diones as dual inhibitors of HIV reverse transcriptase and integrase", Bioorg. Med. Chem. Lett. 2011, 21, 2400-2402.
  • Tang, J.; Maddali, K.; Dreis, C. D.; Sham, Y. Y; Vince, R.; Pommier, Y.; Wang, Z. "N-3 Hydroxylation of Pyrimidine-2,4-diones Yields Dual Inhibitors of HIV Reverse Transcriptase and Integrase.", ACS Med. Chem. Lett. 2011, 2, 63-67.
  • Tang, J.; Maddali, K.; Pommier, Y.; Sham, Y. Y; Wang, Z. “Scaffold rearrangement of dihydroxypyrimidine inhibitors of HIV integrase: Docking model revisited” Bioorg. Med. Chem. Lett. 2010, 20, 3275-3279.
  • Wang, Z.; Tang, J.; Salomon, E. C.; Dreis, C. D.; Vince, R. “Pharmacophore and Structure-Activity-Relationship on Integrase Inhibition within a Dual Inhibitor Scaffold of HIV Reverse Transcriptase and Integrase” Bioorg. Med. Chem. 2010, 18, 4202-4211.