Laurent Bonnac, PhD

Research Assistant Professor, Center for Drug Design (CDD)

Laurent Bonnac

Contact Info

bonna008@umn.edu

Office Phone 612-624-2146

Office Address:
Nils Hasselmo Hall, Room 4-270
312 Church St SE
Minneapolis, MN 55455

Mailing Address:
MMC 204
312 Church St SE
Minneapolis, MN 55455

Research Assistant Professor, Center for Drug Design (CDD)


PhD, University of Montpellier II, France, 2004 (Medicinal chemistry)

Summary

Organic synthesis, medicinal chemistry, nucleoside and nucleotide analogues, antiviral strategies.

Research

Research Summary/Interests

Viruses with pandemic potential such as Dengue, West Nile, Chikungunya, Ebola, MERS, SARS, new strains of influenza and other emerging viruses, represent significant health threats due to the absence of available treatments.

Developing broad spectrum and inexpensive antiviral drugs will be essential in the face of an outbreak crisis. The Center for Drug Design has been committed to antiviral research since its inception upon the successful development of an anti-HIV drug.

Together with Professor Robert Vince and Professor Robert Geraghty we intend to develop broadly acting antiviral strategies by targeting biological pathways shared by many viruses or by targeting general viral population behaviors.

Publications

Publications

  • Clouser Christine L; Bonnac Laurent; Mansky Louis M; Patterson Steven E., Antiviral chemistry & chemotherapy (2013). Characterization of permeability, stability and anti-HIV-1 activity of decitabine and gemcitabine divalerate prodrugs
  • Bonnac, Laurent F.; Mansky, Louis M.; Patterson, Steven E. Journal of Medicinal Chemistry, 2013 Ahead of Print Structure-Activity Relationships and Design of Viral Mutagens and Application to Lethal Mutagenesis
  • Dapp Michael J; Bonnac Laurent; Patterson Steven E; Mansky Louis M. Journal of Virology (2013). Discovery of Novel Ribonucleoside Analogs with Activity Against Human Immunodeficiency Virus Type 1
  • Faramarzalian Ali; McLennan Gordon; Bennett Stacy L; Babsky Andriy; Bansal Navin; Lieber Michael; Bonnac Laurent; Pankiewicz Krystoff; Jayaram Hiremagalur N Journal of vascular and interventional radiology : JVIR (2013), 24(6), 894-900 Variability of apoptosis and response in N1-S1 rodent hepatomas to benzamide riboside and correlation to early changes in water apparent diffusion coefficient and sodium MR imaging
  • McLennan Gordon; Bennett Stacy L; Ju Shenghong; Babsky Andriy; Bansal Navin; Shorten Michelle L; Levitin Seth;Bonnac Laurent; Panciewicz Krystoff W; Jayaram Hiramagular N Cardiovascular and interventional radiology (2012), 35(3), 645-52. Tumor response and apoptosis of N1-S1 rodent hepatomas in response to intra-arterial and intravenous benzamide riboside
  • Lee, Sarah E.; Elphick, Lucy M.; Kramer, Holger B.; Jones, Alexandra M. E.; Child, Emma S.; Anderson, Alexandra A.;Bonnac, Laurent; Suwaki, Natsuko; Kessler, Benedikt M.; Gouverneur, Veronique; et al ChemBioChem (2011), 12(4), 633-640. The Chemoselective One-Step Alkylation and Isolation of Thiophosphorylated Cdk2 Substrates in the Presence of Native Cysteine
  • Bonnac, Laurent; Lee, Sarah E.; Giuffredi, Guy T.; Elphick, Lucy M.; Anderson, Alexandra A.; Child, Emma S.; Mann, David J.; Gouverneur, Veronique Organic & Biomolecular Chemistry (2010), 8(6), 1445-1454. Synthesis and O-phosphorylation of 3,3,4,4-tetrafluoroaryl-C-nucleoside analogs
  • Elphick, Lucy M.; Lee, Sarah E.; Child, Emma S.; Prasad, Aarathi; Pignocchi, Cristina; Thibaudeau, Sebastien; Anderson, Alexandra A.; Bonnac, Laurent; Gouverneur, Veronique; Mann, David J. ChemBioChem (2009), 10(9), 1519-1526. A Quantitative Comparison of Wild-Type and Gatekeeper Mutant Cdk2 for Chemical Genetic Studies with ATP Analogues
  • Elphick, Lucy M.; Lee, Sarah E.; Anderson, Alexandra A.; Child, Emma S.; Bonnac, Laurent; Gouverneur, Veronique; Mann, David J. Future Medicinal Chemistry (2009), 1(7), 1233-1241. Exploring the roles of protein kinases using chemical genetics
  • Lee, Sarah E.; Elphick, Lucy M.; Anderson, Alexandra A.; Bonnac, Laurent; Child, Emma S.; Mann, David J.; Gouverneur, Veronique Bioorganic & Medicinal Chemistry Letters (2009), 19(14), 3804-3807. Synthesis and reactivity of novel ?-phosphate modified ATP analogues
  • Ju Shenghong; McLennan Gordon; Bennett Stacy L; Liang Yun; Bonnac Laurent; Pankiewicz Krzysztof W; Jayaram Hiremagalur N Journal of vascular and interventional radiology : JVIR (2009), 20(3), 410-4 Technical aspects of imaging and transfemoral arterial treatment of N1-S1 tumors in rats: an appropriate model to test the biology and therapeutic response to transarterial treatments of liver cancers
  • Chen, L.; Petrelli, R.; Felczak, K.; Gao, G.; Bonnac, Laurent; Yu, J. S.; Bennett, E. M.; Pankiewicz, K. W. Current Medicinal Chemistry (2008), 15(7), 650-670. Nicotinamide adenine dinucleotide based therapeutics
  • Gao, Guang-Yao; Bonnac, Laurent; Chen, Liqiang; Felczak, Krzysztof; Kullberg, Martin; Petrelli, Riccardo; Bennett, Eric M.; Pankiewicz, Krzysztof W. Abstracts of Papers, 234th ACS National Meeting, Boston, MA, United States, August 19-23, 2007 (2007), CARB-115. Design and synthesis of novel inhibitors of inosine monophosphate dehydrogenase
  • Bonnac, Laurent F.; Gao, Guang-Yao; Chen, Liqiang; Patterson, Steven E.; Jayaram, Hiremagalur N.; Pankiewicz, Krzysztof W. Nucleosides, Nucleotides & Nucleic Acids (2007), 26(10-12), 1249-1253. Efficient Synthesis of Benzamide Riboside, a Potential Anticancer Agent
  • Chen, Liqiang; Gao, Guangyao; Bonnac, Laurent; Wilson, Daniel J.; Bennett, Eric M.; Jayaram, Hiremagalur N.; Pankiewicz, Krzysztof W. Bioorganic & Medicinal Chemistry Letters (2007), 17(11), 3152-3155. Methylenebis(sulfonamide) linked nicotinamide adenine dinucleotide analogue as an inosine monophosphate dehydrogenase inhibitor
  • Bonnac, Laurent; Chen, Liqiang; Pathak, Rashmi; Gao, Guangyao; Ming, Qian; Bennett, Eric; Felczak, Krzysztof; Kullberg, Martin; Patterson, Steven E.; Mazzola, Francesca; et al Bioorganic & Medicinal Chemistry Letters (2007), 17(6), 1512-1515. Probing binding requirements of NAD kinase with modified substrate (NAD) analogues
  • Chen, Liqiang; Gao, Guangyao; Felczak, Krzysztof; Bonnac, Laurent; Patterson, Steven E.; Wilson, Daniel; Bennett, Eric M.; Jayaram, Hiremagalur N.; Hedstrom, Lizbeth; Pankiewicz, Krzysztof W. Journal of Medicinal Chemistry (2007), 50(23), 5743-5751.Probing Binding Requirements of Type I and Type II Isoforms of Inosine Monophosphate Dehydrogenase with Adenine-Modified Nicotinamide Adenine Dinucleotide Analogues
  • Suk, Dae-Hwan; Bonnac, Laurent; Dykstra, Christine C.; Pankiewicz, Krzysztof W.; Patterson, Steven E. Bioorganic & Medicinal Chemistry Letters (2007), 17(7), 2064-2067. Rational design and synthesis of novel nucleotide anti-Giardia agents
  • Bonnac, Laurent; Gao, Guang-Yao; Chen, Liqiang; Felczak, Krzysztof; Bennett, Eric M.; Xu, Hua; Kim, TaeSoo; Liu, Nina; Oh, HyeWon; Tonge, Peter J.; et al Bioorganic & Medicinal Chemistry Letters (2007), 17(16), 4588-4591 Synthesis of 4-phenoxybenzamide adenine dinucleotide as NAD analogue with inhibitory activity against enoyl-ACP reductase (InhA) of Mycobacterium tuberculosis
  • Bonnac, Laurent; Chen, Liqiang; Gao, Guang-Yao; Petrelli, Riccardo; Bennett, Eric M.; Pankiewicz, Krzysztof W. Abstracts of Papers, 234th ACS National Meeting, Boston, MA, United States, August 19-23, 2007 (2007), CARB-111 Synthesis of NAD analogs as selective inhibitors of inosine monophosphate dehydrogenase
  • Chen Liqiang; Rejman Dominik; Bonnac Laurent; Pankiewicz Krzysztof W; Patterson Steven E Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] (2006), Chapter 13, Unit 13.4. Nucleoside-5'-phosphoimidazolides: reagents for facile synthesis of dinucleoside pyrophosphates
  • Bonnac, Laurent; Innocenti, Alessio; Winum, Jean-Yves; Casini, Angela; Montero, Jean-Louis; Scozzafava, Andrea; Barragan, Veronique; Supuran, Claudiu T. Journal of Enzyme Inhibition and Medicinal Chemistry (2004), 19(3), 275-278. Carbonic anhydrase inhibitors: Aliphatic N-phosphorylated sulfamates-A novel zinc-anchoring group leading to nanomolar inhibitors
  • Bonnac, Laurent; Barragan, Veronique; Winum, Jean-Yves; Montero, Jean-Louis Tetrahedron (2004), 60(10), 2187-2190. New pyrophosphate analogues: a facile access to N-(O-alkylsulfamoyl)phosphoramidic acids via a simple and quantitative reaction of N-(O-alkylsulfamoyl)trimethylphospha-?5-azene with bromotrimethylsilane and water

Review Articles and Book Publications

  • Bonnac, Laurent F.; Mansky, Louis M.; Patterson, Steven E. Journal of Medicinal Chemistry, 2013 Ahead of Print Structure-Activity Relationships and Design of Viral Mutagens and Application to Lethal Mutagenesis
  • Elphick, Lucy M.; Lee, Sarah E.; Anderson, Alexandra A.; Child, Emma S.; Bonnac, Laurent; Gouverneur, Veronique; Mann, David J. Future Medicinal Chemistry (2009), 1(7), 1233-1241. Exploring the roles of protein kinases using chemical genetics
  • Chen, L.; Petrelli, R.; Felczak, K.; Gao, G.; Bonnac, Laurent; Yu, J. S.; Bennett, E. M.; Pankiewicz, K. W. Current Medicinal Chemistry (2008), 15(7), 650-670. Nicotinamide adenine dinucleotide based therapeutics
  • Chen Liqiang; Rejman Dominik; Bonnac Laurent; Pankiewicz Krzysztof W; Patterson Steven E Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] (2006), Chapter 13, Unit 13.4. Nucleoside-5'-phosphoimidazolides: reagents for facile synthesis of dinucleoside pyrophosphates