Rohit Singh, PhD

Research Assistant Professor, Center for Drug Design (CDD)

Rohit Singh

Contact Info

singh109@umn.edu

Office Phone 612-624-2146

Office Address:
Nils Hasselmo Hall, 4-270
312 Church St SE
Minneapolis, MN 55455

Mailing Address:
MMC 204
312 Church Street SE
Minneapolis, MN-55455

Research Assistant Professor, Center for Drug Design (CDD)


PhD, University of New Orleans (Organic Chemistry), 2007

MS, University of New Orleans (Organic Chemistry), 2003

MS, Panjab University (Physical Chemistry), 2001

Summary

Awards & Recognition

John C. Stowell Award for Outstanding Teaching Assistants (2006)
Department of Chemistry,
University of New Orleans, New Orleans, LA

University of New Orleans Outstanding Leadership Award (2006-2007)
Student Activities Council, 
University of New Orleans, New Orleans, LA

Professional Associations

American Chemical Society (ACS)

International Union of Pure and Applied Chemistry (IUPAC)

American Association for the Advancement of Science (AAAS)

Research

Research Summary/Interests

Synthetic Organic and Medicinal Chemistry: 
Synthesis and characterization of small molecule medicinal agents
Preparation of libraries of compounds for SAR analysis of biologically relevant targets
Synthesis and application of organic catalysts in metal-free systems


Organometallic Chemistry:
Synthesis of ligands and transition metal-ligand complexes
Experienced in multi-gram scale preparations of ligands
Development of well-defined complexes as effective catalysts for cross-coupling reactions

Publications

  • Puromycin based inhibitors of aminopeptidases for the potential treatment of hematologic malignancies. Rohit Singh*, Jessica Williams, and Robert Vince*. Eur. J. Med. Chem. 2017, 139, 325-336.
  • Nicotinamide Adenine Dinucleotide Based Therapeutics, Update. Krzysztof Pankiewicz, Riccardo Petrelli, Rohit Singh, and Krzysztof Felczak. Curr. Med. Chem. 2015, 22, 3991-4028.
  • 2–Azabicyclo[2.2.1]hept–5–en–3–one: Chemical Profile of a Versatile Synthetic Building Block and its Impact on the Development of Therapeutics. Rohit Singh and Robert Vince, Chem. Rev. 2012,112, 4642-4686.
  • Advances in Synthetic Approaches for the Preparation of Combretastatin based Anti-Cancer Agents. Rohit Singh* and Harneet Kaur, Synthesis 2009, 2471-2491.
  • Synthesis, Characterization and Reactivity of N-Heterocyclic Carbene Gold(III) Complexes. Pierre de Frémont, Rohit Singh, Edwin D. Stevens, Jeffrey Peterson, and Steven P. Nolan, Organometallics 2007, 26, 1376-1385. 
  • N-Heterocyclic Carbenes: Advances in Transition Metal and Organic Catalysis. Rohit Singh, and Steven P. Nolan, Ann. Rep. Prog. Chem. Sect. B 2006, 102, 168-196.
  • Simple (Imidazol-2-ylidene)-Pd-Acetate Complexes as Effective Precatalysts for Sterically Hindered Suzuki-Miyaura Couplings. Rohit Singh, Mihai S. Viciu, Natalia Kramareva, Oscar Navarro, and Steven P. Nolan, Org. Lett. 2005, 7, 1829-1832. 
  • An Efficient and Mild Protocol for the ?-Arylation of Ketones Mediated by an (imidazol-2-ylidene)palladium(acetate) System. Rohit Singh, and Steven P. Nolan, J. Organomet. Chem. 2005, 690, 5832-5840.
  • Synthesis of Phosphorus Esters by Transesterification Mediated by N-Heterocyclic Carbenes (NHCs). Rohit Singh, and Steven P. Nolan, Chem. Commun. 2005, 5456-5458.
  • Transesterification/Acylation of Secondary Alcohols Mediated by N-Heterocyclic Carbene Catalysts. Rohit Singh, Rebecca M. Kissling, Maria-Anne Letellier, and Steven P. Nolan, J. Org. Chem. 2004, 69, 209-212.
  • Transesterification/Acylation Reactions Catalyzed by Molecular Catalysts. Gabriela A. Grasa, Rohit Singh, and Steven P. Nolan, Synthesis 2004, 971-985.
  • Reactivity of N-Heterocyclic Carbene, 1,3-Di-(1-adamantyl) imidazol-2-ylidene, with a Pseudo-Acid: Structural Characterization of Claisen Condensation Adduct. Gabriela A. Grasa, Rohit Singh, Natalie M. Scott, Edwin D. Stevens, and Steven P. Nolan, Chem. Commun. 2004, 2890-2891.
  • Catalytic Activity of Pd(II) and Pd(II)/DAB-R Systems for the Heck Arylation of Olefins. Gabriela A. Grasa, Rohit Singh, Edwin D. Stevens, and Steven P. Nolan, J. Organomet. Chem. 2003, 687, 269-279.
  • Efficient Transesterification/Acylation Reactions Mediated by N-Heterocyclic Carbene Catalysts. Gabriela A. Grasa, Tatyana Guveli, Rohit Singh, and Steven P. Nolan, J. Org. Chem. 2003, 68, 2812-2819.