Early Detection of Alzheimer's Disease Using an Eye Examination

Early Detection of Alzheimer’s Disease Using an Eye Examination

Are you between 40-90 years old?

Do you have Alzheimer’s Disease or know someone who does?

Volunteers needed for an important study being conducted by the

Center for Drug Design
(University of Minnesota)

in collaboration with the

Department of Ophthalmology and Visual Neurosciences

 - Compensation Provided
- Healthy Volunteers also Needed

"This technology is a non-invasive way to identify Alzheimer’s disease before plaque is formed" - Robert Vince, PhD

Researchers at the Center for Drug Design, Profs. Robert Vince, Swati More and Dr. James Beach, have devised a new concept that may allow detection of Alzheimer's disease at an early stage — early enough to give drugs a chance to work! For the first time, changes associated with early stages of the diseases were detected in live mice through color-shifts in the light reflected by the retina. This success, from work with mice predisposed to Alzheimer’s disease, paves a way for a human trial to further test this technique.

A simple eye test will be conducted by a trained health professional and several images of the retina will be acquired by an FDA approved retinal camera. The procedure involved is non-invasive, and does not depend on any extraneous agents. This study is conducted in collaboration with Drs. Ali Mokhtarzadeh and Collin McClelland from the Department of Ophthalmology and Visual Neuroscience at the University of Minnesota.

The study is approved by the University of Minnesota’s Institutional Review Board (Study # 1510M78651). Researchers hope that the data generated will help to engender a better understanding of the pathogenesis of Alzheimer’s disease in the brain and is expected to serve as a tool for early diagnosis of the disease. Importantly, it could also be the key for the development of much-needed drugs for this dreadful disease.

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Swati More 180x222

JBeach 3
Robert Vince, PhD
Director, Center for Drug Design
Professor, Academic Health Center
Swati More, PhD
Assistant Professor,
Center for Drug Design
James M. Beach, PhD
Research Assoc., Center for Drug Design
CytoViva, Inc., Alabama


Collaborators from the Department of Ophthalmology and Visual Neuroscience:
Ali Mokhtarzadeh, MD Assistant Professor, Department of Ophthalmology and Visual Neurosciences
Collin McClelland, MD Assistant Professor, Department of Ophthalmology and Visual Neurosciences