Education & Training

Course Offering: AHS 5100 - HIV Drug Discovery

Spring 2017

Course Details

Course learning objectives

Course learning objectives

Course Learning ObjectivesThis course has been designed to cultivate an understanding of virology, medicinal chemistry, pharmacology, and regulatory aspects related to HIV drug discovery. This course will be most beneficial to students with a strong background in science, and an interest in a career in various aspects of drug discovery.

At the end of the course, students will be able to:

  • Understand the general process and challenges of antiviral drug discovery
  • Understand the basic virology of HIV including the origin, pathogenesis and replication cycle
  • Critically evaluate current journal articles on HIV chemotherapy
  • Identify the types of antivirals currently in development
  • Understand the modes of action of HIV drugs
  • Integrate the concepts of HIV drug discovery by proposing their own chemotherapy strategies for any emerging virus

Prerequisites

Prerequisites

One year of organic chemistry (CHEM 2301 and 2302) or equivalent
AND
One semester of biochemistry (BIOC 3021) or equivalent, are required.

For more information, please contact gerag012@umn.edu.

Course topics

Course topics

Course Topics

  • Overview of antiviral drug discovery
  • Historical review of HIV: origin and controversies
  • HIV pathogenesis, immunology and vaccine
  • HIV replication cycle
  • Target selection
  • Assay development
  • Drug-like properties – General
  • Lead generation strategies
  • Overview of HIV chemotherapy
  • Nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs)
  • Non-nucleoside reverse transcriptase inhibitors (NNRTIs)
  • Protease inhibitors
  • Integrase inhibitors
  • Entry inhibitors
  • Intellectual property in drug discovery
  • Regulatory basics in drug discovery
  • Clinical trials in HIV drug discovery
  • Case study: the invention of abacavir

Reading materials

Reading materials

There is no assigned textbook; however, background reading for each lecture will be posted. These readings will most often be journal articles from the primary research literature but may also be excerpts from text books or internet-based sources. This course will depend heavily on group discussion and class participation.

Credits awarded: 3

Education & Training

Weekly schedule

Weekly Schedule: Tuesdays/Thursdays 9:00 AM - 10:15 AM
Venue: Amundson Hall 240

Course directors

Robert Geraghty, PhD
Associate Professor
Program Director for Biology
Center for Drug Design
PWB 7-215
gerag012@umn.edu

Zhengqiang Wang, PhD
Associate Professor
Program Director for Chemistry
Center for Drug Design
PWB 7-215
wangx472@umn.edu