Functional Cosmetics Protect and Repair Photodamaged Skin
Excessive exposure to the sun not only increases skin cancer risks but also causes premature aging of the skin. Such photodamage manifests itself via increase in epidermal thickness and a change to the skin’s collagen structure. Chronic exposure to sun results in the appearance of wrinkles on the skin giving it an aged look. Specifically, ultra-violet (UV) radiation in sunlight has been identified as the main reason for causing these harmful effects.
Both National Cancer Institute and United States Environmental Protection Agency have endorsed the use of protective cosmetic substances, to be applied topically for the attenuation of harmful effects of UV radiation. However, their utility is often limited by the generation of toxic photodegradation side-products that can be harmful to the skin.
CDD functional cosmetic ingredients
The Center for Drug Design has developed compounds which not only protect the skin from UV damage but also activate the enzymes which repair damaged DNA in the skin. Materials with such unique mechanisms of action have not been previously reported. When skin treated topically with these compounds is exposed to UV light, the epidermal thickness and collagen structure are both maintained (i.e. the skin retains a soft and smooth appearance).
Extensive testing has been completed on these anti-aging compounds and they have been shown to prevent DNA damage and maintain youthful looking skin. The preliminary testing has not indicated the formation of any harmful byproducts or intermediates that may cause skin damage. These compounds not only protect against UV light and reduce the risk of skin cancer, but also give a healthy and smooth appearance to the skin despite sun exposure.
For licensing and other inquiries, please contact Ms. Rebecca Gerber at the Office of Technology Commercialization (OTC) at UMN.
- Effective active ingredients can be the basis for a new skin cosmetic cream, sunscreen or anti-wrinkle sunscreen product line
- Unique mechanism of action could differentiate product from current line of products in the market
- Mechanism of action boosts several key DNA repair enzymes
- Provides protection from photo-damage caused by UV rays, an advantage over other anti-aging products
- Preserves structure of collagen and epidermal thickness
- No formation of toxic photodegradation side-products observed
- Could be added to a wide variety of cosmetic preparations
Current phase of development
Animal and human skin assays (in vivo) have been completed with positive results and United States Patent application has been filed.
Dr. Vince has applied his Medicinal Chemistry and Drug Design expertise to a diverse area of applications including the design of novel antiviral drugs, anti cancer/anti tumor drugs, antidotes to cyanide toxicity and now photo-aging functional cosmetics. He is the inventor of Ziagen,TM a treatment for HIV/AIDS, and has been inducted into the Minnesota Science and Technology Hall of Fame.
- Global UV Index Calculator (EPA)
- Clinical Trials on Premature Aging (NIH)
- Clinical Trials on Sunscreens (NIH)
- Video Discussing Future of Facial Skincare (MINTEL)
- Market Study Report on Anti-Aging Being a Key Motivator When Purchasing Skincare Products (NPD Group)
- Winners of 2012 CEW Beauty Awards (CEW)
Office for Techonology Commercialization contact information
Ms. Rebecca Gerber
Technology Marketing Manager
Office for Technology Commercialization
University of Minnesota
Suite 160, 1000 Westgate Dr
St Paul, MN 55114
Business hours: Monday - Friday, 9 AM through 5 PM (CST)
For additional information
- Visit the OTC website for CDD Functional Cosmetic
- Visit Office for Technology Commercialization (OTC) website
- Visit the technology marketing site to see a list of technologies available through OTC