• Steve P

    Prof Steve Patterson Receives NIH Grant To Develop Cyanide Antidote Autoinjector

    The University of Minnesota Twin Cities and Windgap Medical have received a $3.2 million grant from the National Institutes of Health (NIH) to develop a new device to quickly administer a recently developed antidote for cyanide poisoning. Read More

  • Randy Shaver

    KARE11NEWS

    NBC/KARE11 News: How an eye scan could catch Alzheimer's early

    Watch the video by Heidi Wigdahl: Click Here

  • KSTP-Dan Gilchrest

    Profs Vince and More featured on KSTP-5 Eyewitness News

    Camera at U of M may help researchers detect early signs of Alzheimer's. For the news report by Ellen Galles and to watch the video: Click Here

  • Photo by Susan Kirby-Smith
    Photo by Susan Kirby-Smith

    Prof Christine Salomon's lecture brings large crowd

    Prof Christine Salomon's lecture 'Tales from the underground: Searching for biocontrol treatments for white nose syndrome in bats' drew a big crowd at University of North Carolina. Read More

Message from the Director

Robert Vince

Robert Vince, PhD

The Center for Drug Design (CDD) was created to combine research and scholarship leading to the development of novel drugs for therapeutic applications, such as HIV, cancer, neurological diseases, dermatological agents, infectious diseases, novel processes, and medical devices. The Center for Drug Design combines the best of academic tradition along with an expectation of innovation and independence, and provides significant value  for our academic and research community.

Next Seminar

Zlotnick Adam
Professor
Department of Molecular & Cellular Biochemistry
Indiana University
Wednesday, March 11, 2020 - 10:30am to 11:30am
Location:

3-125 Mayo Atrium

Title: Virus Biophysics as a Basis for Developing Antivirals

About half of viruses have a spherical proteinaceous capsid that has roles in protecting and delivering the viral genome.  In most cases, the capsid is a self-assembling oligomer.  Observations of capsid assembly show that the self-assembly reaction follows a few relatively simple rules based on weak local interactions that result in a steep downhill energy gradient.  In short, it is easy to drive assembly forward.  Virus capsid proteins are specific to the virus, consequently, molecules that fit a protein-protein interface for the virus can be highly specific.  We have pursued assembly-directed antivirals to Hepatitis B Virus (HBV) that drive capsid assembly and lead to aberrant structures.These block formation of new virus and can, in emergent behavior, disrupt pre-formed capsids. Thus, at least two distinct mechanisms of action can arise from a single antiviral.

Detecting Alzheimer's with an Eye Exam: Video

Detecting Alzheimer's with an Eye Exam