Prof Steve Patterson Receives NIH Grant To Develop Cyanide Antidote Autoinjector
The University of Minnesota Twin Cities and Windgap Medical have received a $3.2 million grant from the National Institutes of Health (NIH) to develop a new device to quickly administer a recently developed antidote for cyanide poisoning. Read More
NBC/KARE11 News: How an eye scan could catch Alzheimer's early
Watch the video by Heidi Wigdahl: Click Here
Profs Vince and More featured on KSTP-5 Eyewitness News
Camera at U of M may help researchers detect early signs of Alzheimer's. For the news report by Ellen Galles and to watch the video: Click Here
Photo by Susan Kirby-Smith
Prof Christine Salomon's lecture brings large crowd
Message from the Director
The Center for Drug Design (CDD) was created to combine research and scholarship leading to the development of novel drugs for therapeutic applications, such as HIV, cancer, neurological diseases, dermatological agents, infectious diseases, novel processes, and medical devices. The Center for Drug Design combines the best of academic tradition along with an expectation of innovation and independence, and provides significant value for our academic and research community.
3-125 Mayo Atrium
Title: Virus Biophysics as a Basis for Developing Antivirals
About half of viruses have a spherical proteinaceous capsid that has roles in protecting and delivering the viral genome. In most cases, the capsid is a self-assembling oligomer. Observations of capsid assembly show that the self-assembly reaction follows a few relatively simple rules based on weak local interactions that result in a steep downhill energy gradient. In short, it is easy to drive assembly forward. Virus capsid proteins are specific to the virus, consequently, molecules that fit a protein-protein interface for the virus can be highly specific. We have pursued assembly-directed antivirals to Hepatitis B Virus (HBV) that drive capsid assembly and lead to aberrant structures.These block formation of new virus and can, in emergent behavior, disrupt pre-formed capsids. Thus, at least two distinct mechanisms of action can arise from a single antiviral.