Cosmetic and Possible Future Pharmaceutical Applications
Cosmetic Antioxidant Synergist
A proprietary biomimetic decoy molecule enhances skin's innate ability to manage UV induced damage and inhibit damage caused by Reactive Oxygen Species [ROS]. Data shows reduction and clearance of Cyclobutane Pyrimidine Dimers [CPDs]. Ongoing scientific studies are continuing to reveal potential new applications.
Benefits and Applications
Cosmetics
Anti-aging skincare
Provides a collagen rich experience
Helps improve the apperance of hyperpigmentation and premature aging
Aids in mositurization
Non-sensitizing
Non-irritating
Non-toxic
Unscented
Biomimetic
Ongoing Reserach for Future Applications
Anti-photoaging products
Enahnaced skincare for sun defense
Reverses damage and oxidative stress caused by UV exposure
Maintenance of epidermal layer and collagen structure
Personal care products
Scientific Research (On going)
From the University of Minnesota, Center for Drug Design
Protexidine™ Study
The study supports that ProteXidineTM in an ex vivo skin model reduces CPD formation, a damaging effect of UV exposure.
Human ex vivo skin cultures show that ProteXidine can reduce formation of CPDs following UV exposure
Skin treated with ProteXidine and then UV irradiated showed little formation of CPDs 4 hours after UV exposure, and 12 hours after UV exposure shows next to none remaining, as compared to untreated skin.
Fig 1. Untreated Skin with No ProteXidine
Fig 2: Treated Skin with ProteXidine. Skin 4 h after UV exposure
Fig 3: Untreated Skin with No ProteXidine. Skin 12 h after UV exposure
Fig 4: Treated Skin with ProteXidine. Skin 12 h after UV exposure
Fig 5: Untreated Skin with No ProteXidine
Fig 6: Treated Skin with ProteXidine. Skin 4 h after UV exposure
Fig 7: Untreated Skin with No ProteXidine
Fig 8: Treated Skin with ProteXidine. Skin 12 h after UV exposure
Evidence in human skin explants shows that ProteXidine increases the clearance of damaged epidermal cells (black arrows) inducing replacement with healthy new cells.
Fig 1: Untreated skin with UV exposure: Collagen density is reduced with loss of basketweave structure
Fig 2: Untreated skin without UV exposure: Normal collagen with basketweave structure preserved
Fig 3: Skin treated skin with ProteXidine and UV exposure: Collagen density and basket-weave structure maintained
The Center for Drug Design (CDD), part of the University of Minnesota College of Pharmacy, created a novel technology using biomimetic decoy molecules to boost the skin's natural ability to mitigate ultraviolet-induced damage, a development that has the potential to revolutionize the skincare industry.
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