ProteXidine™: A Functional Cosmetic Enhancing Skin Appearance

Three people taking selfie picture at the beach


Unparalleled Skin Benefits from ProteXidine—A New, Novel, Patented and Clinically Proven Molecule to Enhance the Skin’s Appearance 

A functional cosmetic portfolio offers UV protection and improves the skin’s appearance, providing a more youthful and healthier look. ProteXidine, a new molecule that complements antioxidants and works synergistically with key elements of cosmetic wellness and beauty regimens to provide visible changes in tone, texture, firmness, and smoothness, as well as a collagen-rich appearance and a more hydrated, glowing appearance, was developed at the University of Minnesota, Center for Drug Design.

ProteXidine is Designed to be Compatible with Sunscreens

Excessive exposure to the sun increases skin cancer risk and can cause premature aging of the skin, increased epidermal thickness and changes in collagen structure. In addition, active ingredients in most sunscreens absorb light upon UV exposure but may generate very reactive intermediates (reactive oxygen species, ROS), which can crosslink collagen and may cause unwanted allergic reactions or sunburns. ProteXidineTM is compatible with sunscreens and the addition of antioxidants to sunscreens has proven cosmetic benefits.

Cosmetic Benefits and Applications

Benefits and Features 

  • Skin anti-aging 
  • Non-toxic 
  • Supports the epidermis and collagen structure and levels in the skin 
  • Skin Conditioner 
  • Non-irritating 
  • Non-sensitizing 
  • Beautifies the complexion


  • After sun care products 
  • Anti-aging technology 
  • Anti-wrinkle creams 
  • Bathing product lines 
  • Cosmetics 
  • Functional cosmetic ingredients 
  • Cosmeceuticals 
  • Personal care products 
  • Sun cosmetics Sunscreens, as an antioxidant
Scientific Research (ongoing)

Current products offer some help but have several disadvantages. For example, DNA repair cosmetics are generally large molecular weight protein structures known for low stability and poor absorption. Such enzyme-based products do not stimulate production of key repair enzymes. They help only in late-stage repair mechanisms and require expensive formulations to increase efficacy and stability.

Benefits and Features

  • Photoprotection
  • Natural stimulation of DNA repair enzymes
  • Protects DNA from UV damage
  • Bio-mimetics
  • UV-B protection
  • Reverse damage and oxidative stress caused by UV exposure


  • Support DNA repair mechanisms
  • Maintenance of epidermal layer
  • Novel anti-aging products
  • UV protection
  • Enhanced skincare for sun defense
  • UV/UV-B absorbers
  • Skin needs that that affect pigmentation balance

Meet the Team

Robert Vince, PhD
Professor and Founding Director, Center for Drug Design

Abbas Raza, PhD
Research Associate Professor;
Head, Cosmetic Science and Product Innovation 
Center for Drug Design

Christine Dreis
Senior Scientist,
Center for Drug Design