ProteXidine™: A Functional Cosmetic Enhancing Skin Appearance

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Overview

Introducing ProteXidine™

  • Patented Technology
  • Cosmetic and Possible Future Pharmaceutical Applications
  • Cosmetic Antioxidant Synergist

A proprietary biomimetic decoy molecule enhances skin's innate ability to manage UV induced damage and inhibit damage caused by Reactive Oxygen Species [ROS]. Data shows reduction and clearance of Cyclobutane Pyrimidine Dimers [CPDs]. Ongoing scientific studies are continuing to reveal potential new applications.

Benefits and Applications

Cosmetics

  • Anti-aging skincare
    • Provides a collagen rich experience
    • Helps improve the appearance of hyperpigmentation and premature aging
    • Aids in moisturization
  • Non-sensitizing
  • Non-irritating
  • Non-toxic
  • Unscented
  • Biomimetic

Ongoing Research for Future Applications

  • Anti-photoaging products
  • Enhanced skincare for sun defense
  • Reverses damage and oxidative stress caused by UV exposure
  • Maintenance of epidermal layer and collagen structure
  • Personal care products
Scientific Research (On going)

ProteXidine™ Study

From the University of Minnesota, Center for Drug Design 

The study supports that ProteXidineTM in an ex vivo skin model reduces CPD formation, a damaging effect of UV exposure.

  • Human ex vivo skin cultures show that ProteXidine can reduce formation of CPDs following UV exposure
  • Skin treated with ProteXidine and then UV irradiated showed little formation of CPDs 4 hours after UV exposure, and 12 hours after UV exposure shows next to none remaining, as compared to untreated skin.
Untreated Skin with No ProteXidine
Fig 1. Untreated Skin with No ProteXidine 
Treated Skin with ProteXidine
Fig 2: Treated Skin with ProteXidine. Skin 4 h after UV exposure
Untreated Skin with No ProteXidine
Fig 3: Untreated Skin with No ProteXidine. Skin 12 h  after UV exposure
IHC after 12 h
Fig 4: Treated Skin with ProteXidine. Skin 12 h after UV exposure

 

Untreated Skin with No ProteXidine
Fig 5: Untreated Skin with No ProteXidine
Treated Skin with ProteXidine
Fig 6: Treated Skin with ProteXidine. Skin 4 h after UV exposure
Untreated Skin with No ProteXidine
Fig 7: Untreated Skin with No ProteXidine 
Treated Skin with ProteXidine. Skin 12 h after UV exposure
Fig 8: Treated Skin with ProteXidine. Skin 12 h after UV exposure

Evidence in human skin explants shows that ProteXidine increases the clearance of damaged epidermal cells (black arrows) inducing replacement with healthy new cells.

Untreated skin with UV exposure
Fig 1: Untreated skin with UV exposure: Collagen density is reduced with loss of basketweave structure
Untreated skin without UV exposure
Fig 2: Untreated skin without UV exposure: Normal collagen with basketweave structure preserved
Skin treated skin with ProteXidine and UV exposure
Fig 3: Skin treated skin with ProteXidine and UV exposure: Collagen density and  basket-weave structure  maintained
Meet the Team

Robert Vince, PhD 

Founding Director & Professor, Center for Drug Design 

Abbas Raza, PhD 

Head, Cosmetic Science and Product Innovation, & Research Associate Professor, Center for Drug Design

Christine D. Dreis 

Senior Scientist, Center for Drug Design

ProteXidine™ Story

CDD's ProteXidine™ in the news

The Center for Drug Design (CDD), part of the University of Minnesota College of Pharmacy, created a novel technology using biomimetic decoy molecules to boost the skin's natural ability to mitigate ultraviolet-induced damage, a development that has the potential to revolutionize the skincare industry.

Read more about ProteXidine™