Abbas Raza, PhD

Research Associate Professor, Center for Drug Design (CDD)
Abbas R


Office Phone
Office Address

Nils Hasselmo Hall, 4-270
312 Church St SE
Minneapolis, MN 55455
United States


Research Associate Professor, Center for Drug Design (CDD)
Head, Cosmetic Science and Product Innovation, CDD


PhD, Indian Institute of Chemical Technology (Organic Chemistry)

MS, University of Hyderabad (Chemistry)


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Research summary/interests


  • Design of functional cosmetic ingredients
  • Biomimetic DNA repair and anti-skin aging approaches
  • New photoprotection strategies (Solar UV)

Vitamin C:
In addition to being an antioxidant, ascorbic acid (AA) in its oxidized form, dehydroascorbic acid (DHA) has many important biological functions beyond the AA–DHA cycle. Current research include exploring the other facets of this important molecule and use the knowledge to make an effective dug like molecule.


  • HIV-1 Protease inhibitors
  • HCV NS3 Protease inhibitors


  • Vince, R, More SS and Raza, A. Therapeutic Compounds and Methods, US 11,479,579 B2, 2022
  • Vince, R, Raza, A and Dreis C. Sunless Tanning Compounds and Compositions, US 9,987,211 B2, 2018
  • Vince, R,  Raza A and Dreis C. Agents that Prevent or Repair Skin Damage, US 9,403,778 B2, 2016
  • Vince, R, Raza, A and Dreis C. Open chained or fused 1,1′-alkylene-bis-uracil derivatives, useful in skin UV-protection, US 9,364,406 B2, 2016



  • Dipeptide of ψ-GSH Inhibits Oxidative Stress and Neuroinflammation in an Alzheimer's Disease Mouse Model. Raza A, Xie W, Kim KH, Dronamraju VR, Williams J, Vince R, More SS. Antioxidants (Basel). 2022 May 28;11(6):1075. 
  • Orally Bioavailable Prodrugs of ψ-GSH: A Potential Treatment for Alzheimer's Disease. Xie W, Cao B, Zhu H, Raza A, Juckel N, Xie J, Jiang R, Vince R, Lee MK, More SS. J Med Chem. 2022 Nov 10;65(21):14441-14455.
  • Topical Acyclothymidine Dinucleosides (aTds) Promote non-UV Mediated Endogenous Defense Mechanisms in Guinea Pig Skin. Nugent, S. N, Vince, R. Raza, AJ. Invest. Dermatol. 2015, 135, 1687-89.
  • A Bio-Mimetic Approach to DNA Photoprotection Raza, A.; Ericson, M. E.; Nugent, J. S.; Dreis, C. D.; Vince, R. J. Invest. Dermatol. 2014, 134, 559–562.
  • Photoprotection of DNA (in vitro) by acyclothymidine dinucleosides. Raza, A.; Dreis, C. D.; Vince, R. Bioorg Med Chem Lett. 2013, 23(3), 620-3.
  • The Butter Flavorant, Diacetyl, Forms a Covalent Adduct with 2-Deoxyguanosine, Uncoils DNA, and Leads to Cell Death. More, S. S.; Raza, A; Vince, R. J. Agric. Food Chem. 2012, 60 (12), 3311-3317.
  • Dehydroascorbic Acid Adducts of Guanosine Residues: Possible Biological Implications. Raza, A. and Vince, R. ChemBioChem 2011, 12, 1015-1017.
  • Design and synthesis of sulfoximine based inhibitors for HIV-1 protease. Raza, A.; Sham, Y. Y. and Vince, R. Bioorg. Med. Chem. Lett. 2008, 18, 5406-5410.
  • Solid-Phase Synthesis of Isoxazolines. Raza, A.; Reddy, M. V.; Yadav, J. S; Chandrasekhar, S. J. Comb. Chem. 2002, 4(6), 652-655.
  • Synthesis of unusual amino acids: N-(tert-butoxycarbonyl)-L-vinyl glycine and N-(tert-butoxycarbonyl)-L-homophenylalanine. Raza, A.; Takhi, M.; Chandrasekhar, S. Tet. Asymm. 2002, 13(4), 423-428.
  • A New Cleavage Strategy for Ester Linked Polymer Supports: Generation of a Tertiary Alcohol Library. Padmaja, M. B.; Raza, A.; Chandrasekhar, S. J. Comb. Chem. (2000), 2(3), 246-248.
  • Solid phase-solid state synthesis of N-alkyl imides from anhydrides. Padmaja, M.B.; Raza, A.; Chandrasekhar, S. Synlett, 1999, 1597.
  • Novel solid-state reduction of organic functional groups on solid support (Merrifield's resin). Raza, A.; Padmaja, M. B.; Chandrasekhar, S. Synlett 1999, (7), 1061-1062.
  • One pot synthesis of acetylated homoallyl alcohols. Mohanty, P. K.; Raza, A.; Chandrasekhar, S. Synth. Commun. 1999, 29(2), 257-262.