Christine Salomon, PhD

Associate Professor, Center for Drug Design (CDD)
Christine-Salomon headshot


Office Address

Nils Hasselmo Hall, Room 4-130
312 Church St. SE, MN 55455
United States


Associate Professor, Center for Drug Design (CDD)


PhD, Scripps Institution of Oceanography, 2001

Southampton College, 1995

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Professional Associations

Graduate Faculty, Microbial Engineering

Adjunct Assistant Professor, Biotechnology Institute

Research Summary

The overarching goal of our research program is to discover novel natural products with useful biological activities. Chemical extracts are obtained from cultures of environmental bacterial and fungi that are collected from diverse field locations. Bioassay guided fractionation is used to purify compounds with activity against a panel of human bacterial and fungal pathogens, cancer cell lines and pathogenic biofilms.

Additional screens include an oxidative protection assay and enhancement of limb regeneration in animal models. Novel compounds with potent biological activities are studied to identify the critical pharmacophores which may provide lead structures for new therapeutics or strategies to treat infectious disease, cancer and neurodegenerative disorders.

Active compounds may also provide useful tools to study biosynthetic pathways, signaling cascades, drug resistance, and novel mechanisms of inhibition. Additional areas of interest include biocontrol of agricultural pathogens and the elucidation and modulation of communication networks among bacterial populations using natural products.


  • A nontoxic fungal natural product modulates fin regeneration in zebrafish larvae upstream of FGF‐WNT developmental signaling. Paul Cavanah, Junji Itou, Yudi Rusman, Naoyuki Tahara, Jessica M. Williams, Christine E. Salomon, Yasuhiko Kawakami, Developmental Dynamics. 2020; 1–15. (Abstract)
  • Diverse subterranean fungi of an underground iron ore mine. Benjamin W. Held, Christine E. Salomon, Robert A. Blanchette. PLOS ONE 2020, 15(6): e0234208. (Abstract)
  • Discovery of antifungal and biofilm preventative compounds from mycelial cultures of a unique North American Hericium sp. fungus. Xun Song, François Gaascht, Claudia Schmidt-Dannert, Christine E SalomonMolecules, 2020, 25, 963. (Abstract)
  • Antifungal norditerpene oidiolactones from the fungus Oidiodendron truncatum, a potential biocontrol agent for white-nose syndrome in bats. Yudi Rusman, Michael B. Wilson, Jessica M. Williams, Benjamin W. Held, Robert A. Blanchette, Brianna N. Anderson, Christopher R. Lupfer, Christine E. SalomonJournal of Natural Products 2020, 83, 344-353. (Abstract)
  • Cadopherone and colomitide polyketides from Cadophora wood-rot fungi associated with historic expedition huts in Antarctica. Rusman Y, Held B, Blanchette RA, Salomon CEPhytochemistry 2018, 148, 1-10. (Abstract)
Salmon research diagram
  • Resource capture and competitive ability of non-pathogenic Pseudogymnoascus spp. and P. destructans, the cause of white-nose syndrome in bats. Wilson MB, Held BW, Freiborg AH, Blanchette RA, Salomon CEPLoSONE 2017, 12(6): e0178968. (Abstract)
  • Complete genome of Streptomyces albus SM254, a potent antagonist of bat white-nose syndrome pathogen Pseudogymnoascus destructans. Badalamenti JP, Erickson JD, Salomon CE. Genome Announcements 2016, 4(2):e00290-16.
  • Growth inhibition and apoptosis in prostate and breast cancer cells induced by polyphenolic compounds of Acacia hydaspica R. Parker: Involvement of multiple signal transduction pathways. Afsar, T, Trembley, JH, Salomon, CE, Razak, S, Khan, MR, Ahmed, K. Scientific Reports 2016, in press.
  • Soudanones A-G: Antifungal isochromanones from the ascomycetous fungus Cadophora sp. isolated from an iron mine. Rusman Y, Held B, Blanchette R, Wittlin S, Salomon CEJournal of Natural Products 2015, 78, 1456-1460.
  • Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family ProteinsHassig CA, Zeng F-Y, Kung P, Kiankarimi M, Kim S, Diaz PW, Zhai D, Welsh K, Morshedian S, Su Y, O'Keefe B, Newman DJ, Rusman Y, Kaur H, Salomon CE, Brown SG, Baire B, Michel AR, Hoye TR, Francis S, Georg GI, Walters MA, Divlianska DB, Roth GP, Wright AE, Reed JC Journal of Biomolecular Screening 2014, doi:10.1177/1087057114536227
  • Synthesis and evaluation of N-alkyl-9-aminoacridines with antibacterial activity. Benoit AR, Schiaffo C, Yang J, Salomon CE, Ji Y, Goodell J, Ferguson, DM. Bioorgic and Medicinal Chemistry Letters 2014, 24, 3014–3017.
  • Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines. Temburnikar KW, Zimmermann S, Kim NT, Ross CR, Gelbmann C, Salomon CE, Wilson GM, Balzarini J, Seley-Radtke KL. Bioorganic and Medicinal Chemistry 2014, 22, 2113-2122. 
  • Subinhibitory antibiotic concentrations alter nutrient utilization and niche overlap among Streptomyces spp. Vaz P, Bakker M, Salomon CE, Kinkel LL. Plos One 2013, 8 (12): e81064.
  • Solphenazines A-F: Glycosylated phenazines from Streptomyces sp. strain DL-93. Rusman Y, Oppegard LM, Hiasa H, Gelbmann C, Salomon CEJournal of Natural Products 2013, 76, 91-96.
  • Pathogen variation and urea influence selection and success of Streptomyces mixtures in biocontrol. Otto-Hanson LK, Grabau Z, Rosen C, Salomon CE, Kinkel LL. Phytopathology 2013, 103, 34-42. 
  • Total synthesis and biological evaluation of the structure of (+)-transvalencin Z. Nelson KM, Salomon CE, Aldrich CA.Journal of Natural Products 2012, 75, 1037-1043. 
  • Natural products as leads for tuberculosis drug development. Salomon CE, Schmidt LE. Current Topics in Medicinal Chemistry 2012, 12, 735-765. 
  • Dual inhibitors of HIV reverse transcriptase and integrase: Structure-activity-relationship studies on integrase inhibition.Wang Z, Tang J, Salomon C, Dreis C,Vince R. Bioorganic and Medicinal Chemistry 2010, 18, 4202-4211. 
  • Plant signaling compounds alter secondary metabolite production among antagonistic streptomyces. Bakker MG, Salomon CE, Kinkel LL. Phytopathology 2009, 99(6): S7-S8.
  • Structure and cytotoxicity of arnamial and related fungal sesquiterpene aryl esters. Misiek M, Williams J, Schmich K, Huttel W, Merfort I, Salomon CE, Aldrich CC, Hoffmeister D. Journal of Natural Products 2009, 72, 1888-1891. (Abstract)
  • Biosynthesis of Ubiquinone Compounds with Conjugated Prenyl Side ChainsLee PC, Salomon CE, Mijts B, Schmidt-Dannert C. Applied and Environmental Microbiology 2008, 74, 6908-6917. (Abstract)
  • Rationally designed dual inhibitiors of HIV reverse transcriptase and integrase. Wang Z, Bennett EM, Wilson DJ, Salomon CE, Vince R. Journal of Medicinal Chemistry 2007, 50, 3416-3419. (Abstract)
  • Gene transfer in gram positive bacteriaKristich C, Salomon CE, Dunny G. Methods for General and Molecular Bacteriology, Gerhardt R, Ed., American Society for Microbiology, Washington, D.C., USA. 2007.
  • Total synthesis of narbonolide and biotransformation to pikromycin: Effect of protecting groups on the intramolecular Nozaki–Hiyama–Kishi coupling of 14-membered macrolides. Venkatraman L, Salomon CE, Sherman DH, Fecik R. J. Org. Chem. 2006, 71, 9853-9856. (Abstract)
  • Merging the potential of microbial genetics with marine biological and chemical diversity: An even brighter future for marine natural product drug discoverySalomon CE, Magarvey NA, Sherman DH. Natural Product Reports 2004, 21, 105-121. (Abstract)
  • Localization studies of bioactive cyclic peptides in the ascidian Lissoclinum patella. Salomon CE, Faulkner DJ. Journal of Natural Products. 2002, 65, 689-692. (Abstract)
  • Relative and absolute stereochemistry of the didemnaketals, metabolites of a Palauan ascidian, Didemnum sp.Salomon CE, Williams DH, Lobkovsky E, Clardy JC, Faulkner DJ. Organic Letters. 2002, 4, 1699-1702. (Abstract)
  • The cellular localization of the pyridoacridine dercitamide in the Palauan sponge Oceanapia sagittaria. Salomon CE, Deerinck T, Ellisman M, Faulkner DJ. Marine Biology 2001, 139, 313-319. (Abstract)