As a member of the CDD BioCore, I provide biochemistry and molecular pharmacology support for the early phases of multiple drug discovery projects within the Center. My current research efforts are focused on several DNA- and RNA-processing enzymes involved in viral replication, and on G protein-coupled receptors involved in pain and neuroinflammation. In each case, I use
purified proteins and cell-based assays to analyze the basic function of target proteins and identify new molecules modulating their activity.