Pharmacology Core

• The Center for Drug Design (CDD) Pharmacology Core aims to facilitate medicinal chemists' efforts to discover new lead candidates with proper drug-like properties, and to obtain research funding and publish academic research findings.
   
• The Pharmacology core is supported by the CDD and was initially established to provide high-quality ADMET, PK, and toxicology studies. Since 2014, our work has contributed to the successful funding of 7 NIH grants and the publication of more than 40 peer‑reviewed papers.

• The Pharmacology Core is equipped with a state-of-the-art LC-MS instrument (Agilent 1260 HPLC and AB Sciex QTrap 5500 MS) that is used to detect and quantitate small molecules in biological matrices.
• The Core also manages an Agilent 6230B Time of Flight LC/MS system with capability of high resolution mass. 
• The Core has licensed Phoenix WinNonlin software for PK data analysis and modeling.
   

LC/MS/MS bioanalytical services

• Express LC/MS/MS method development
• Advanced LC/MS/MS bioanalytical method development and validation in accordance with the ICH M10 guideline
• Quantitative analysis of small molecules in biological matrices

In vitro ADMET

• Microsomal stability, Plasma stability, S9 stability, Aqueous stability
• Cytochrome P450 inhibition, Cytochrome P450 reaction phenotyping
• Plasma protein binding, Brain tissue binding, Blood to plasma ratio
• Solubility
• Caco-2, MDCK and PAMPA permeability
• hERG Assay 

Rodent PK and Toxicology 

• Oral bioavailability of drugs in mice and rats
• PK Data analysis with non-compartmental or compartmental models
• Single dose toxicology (Acute Toxicity) in mice and rats
• Repeat dose toxicology in mice and rats 

Zhengqiang (ZQ) Wang, PhD 
Professor, Co-Director
[email protected]
 

Jiashu Xie, PhD
Assistant Professor
Core Manager
[email protected]

Wei Xie, MD
Senior Staff Scientist
Tox
[email protected]

Roshan Katekar, PhD
Postdoc
ADME / PK 
[email protected]